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Mini Med School VII - The Brain!


Nutrition, exercise and plasticity Q & A

Q: I understand that you also study MS in kids. I have MS and have heard that a "starvation" diet sometimes works well for MS, but I haven't tried it. Have you tried the ketogenic diet on kids with MS?  Or are there any dietary recommendations for children of parents with MS so they don't get it?   

Dr. Kati Wambera:

A: The ketogenic diet has never been tried in MS either in people or in animals. The disease is so different in epilepsy vs in MS that I would doubt that it would have a similar effect. I would not recommend a dietary change in the children of people with MS.

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Q: Does the ketogenic diet work in adults with brain tumours?  

Dr. Kati Wambera:

A: The ketogenic diet has only been used in animal research in the context of brain tumours. It has never been tried in humans, adults or children. It is likely that when human research trials they will begin in children, where Dr.s have the most experience with the ketogenic diet.

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Q: How do you taper off the ketogenic diet?  is it slowly adding more sugars?  

Dr. Kati Wambera:

A: We slowly decrease the total amount of fat to the combined carbohydrate and protein, say from a 4:1 fat: carb/protein to 3:1 fat: carb/protein  

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Q: Why does the ketogenic diet work better in children until 12 years of age?   Why doesn't it work in adults?  

Dr. Kati Wambera:

A: We don't know why it works differently at different ages, predominantly because we don't really know how it works at all. It may be that the adult body reacts differently. Once the ketogenic diet becomes more main stream in pediatric epilepsy, I suspect there will be more pressure to try it again in adults.

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Q: Since it was found that malignant tumours don't like ketones, why don't we start using the ketogenic diet as a treatment for some brain tumours instead of surgery?  The diet would be less risky.   

Dr. Kati Wambera:

A: That was purely 'cutting' edge animal research. We don't know how tumours would react in humans. I suspect that we will see nterest in human research in this area in the near future.

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Q: Does the Atkins diet have similar affects as the ketogenic diet?  does our body mimic starvation? 

Dr. Kati Wambera:    

A: The ketogenic diet is like Atkin +++, they work in very similar ways, but the Atkins diet is less extreme. Some epilepsy centres suggest that their patients start on the Atkin's diet while they are on the waitlist for the ketogenic diet. It has not been shown to be as effective as the ketogenic diet

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